Clinical Trials Detalhe
Nuclear Magnetic Resonance for Embryo Ploidy Selection
Visão Geral
Gender
FEMALE
Idade
from 18 Years to 48 Years
Fase
N/D
Tipo de Estudo
OBSERVATIONAL
Localização
Instituto Valenciano de Infertilidade (Lisbon, Portugal)
Clinicaltrial.gov
https://classic.clinicaltrials.gov/ct2/show/NCT05488236Sumário
This study aims to validate the embryo culture medium analysis by nuclear magnetic resonance spectroscopy, as a faster and less-costly alternative to preimplantation genetic test for aneuploidy which could significantly enhance embryo selection and the success rate of assisted reproductive technologies.
Condições
Aneuploidy
Infertility
Elegibilidade
Inclusion Criteria: * Age: ≥18 and \<49 years old. * Body Mass Index ≥18.5 Kg/m2 and \<30 Kg/m2. * Planned for in vitro fertilization followed by preimplantation genetic test for aneuploidy. * Oocytes retrieval and fertilization by intracytoplasmic sperm injection * Six follicles over 14 mm on the day of the triggering. Gonadotropin-releasing hormone antagonist * Signed and dated informed consent. Exclusion Criteria: * Previous history of poor ovarian response (\<4 oocytes retrieved) with a maximal dose of ovarian stimulation (≥300 IU/day). * Presence of a medical condition which is known to affect assisted reproductive technologies outcome (e.g. thyroid dysfunction). * Active female smoking. * Current use of anti-depressants, anti-psychotics, steroids, antiepileptics or chemotherapy. * Those unable to comprehend the investigational nature of the proposed study.